While coach Rassie Erasmus has named a more conventional set of replacements, with five specialist forwards rather than the seven he has experimented with in the past, former Harlequins centre Andre Esterhuizen has been deployed as a flanker off the bench in the past.
Cheslin Kolbe and Damian Willemse will both win their 50th caps as part of the starting line-up.
“England are a quality outfit, and we are expecting them to give everything they have in this match, so it was important to select a squad with experience combined with a few younger players, who have proved that they have what it takes to perform at this level,” said Erasmus, whose team beat a Barbarians side 80-31 in a warm-up fixture on 20 June.
England’s team announcement is expected towards the end of this week.
South Africa: Willemse; Kolbe, Kriel, De Allende, Arendse; Libbok, Williams; Nche, Marx, T du Toit, Etzebeth, Nortje, Kolisi, P-S du Toit, Wiese
Replacements: Wessels, Steenekamp, Porthen, Van Staden, Hanekom, Reinach, Esterhuizen, Moodie
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